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March 23, 2018  |  Login
By James F. Balch, M.D. and Mark Stengler, N.D.
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Description: Ipriflavone is a synthetic copy of a soy flavonoid known as daidzein. It is used as a supplement for the maintenance and the enhancement of bone density. Animal and human studies have shown that when combined with calcium and other minerals, it stimulates bone building by increasing the cells that form bone (osteoblasts) and reducing the activity of cells that break down bone (osteoclasts).


  • Hyperparathyroidism
  • Kidney failure (to maintain bone density)
  • Osteoporosis
  • Otosclerosis
  • Paget's disease

Precautions: Digestive upset is the most common side effect, which can be ameliorated by taking ipriflavone with food. One study found that lymphocyte count decreased in 29 out of 132 women who were supplementing ipriflavone. This reduction was not regarded as clinically significant, but it is recommended to have your doctor monitor these white blood cells.

Dosage: Take 600 mg daily.

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